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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LEO1
All Species:
10
Human Site:
S135
Identified Species:
20
UniProt:
Q8WVC0
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8WVC0
NP_620147.1
666
75404
S135
H
H
S
E
A
E
G
S
E
K
A
H
S
D
D
Chimpanzee
Pan troglodytes
XP_001170061
606
67985
D95
S
E
A
S
E
R
S
D
H
E
D
N
D
P
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535485
665
75345
S135
H
H
S
E
A
E
G
S
E
K
A
H
S
D
D
Cat
Felis silvestris
Mouse
Mus musculus
Q5XJE5
667
75623
S135
R
H
S
E
A
E
G
S
E
K
A
Q
S
D
D
Rat
Rattus norvegicus
Q641X2
678
76939
K147
S
E
A
E
G
S
E
K
A
Q
S
D
D
E
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512640
354
40227
Chicken
Gallus gallus
XP_413803
627
71376
D116
A
A
H
D
D
E
E
D
E
R
G
H
G
S
D
Frog
Xenopus laevis
Q52KV5
703
80388
N167
D
E
E
E
K
M
Q
N
S
D
D
E
L
Q
H
Zebra Danio
Brachydanio rerio
Q6NYV9
696
76423
M135
H
S
D
N
E
H
S
M
S
E
A
H
R
G
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94546
725
77404
A164
R
S
R
K
S
G
S
A
Q
S
D
R
S
E
S
Honey Bee
Apis mellifera
XP_624295
603
67203
S92
G
S
T
H
S
Q
K
S
G
S
Q
R
S
R
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781595
591
67675
G80
E
Y
E
E
M
V
E
G
E
G
E
E
G
E
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.9
N.A.
97.7
N.A.
93.4
92.1
N.A.
47.5
78.8
70.9
60.3
N.A.
32.5
36.3
N.A.
42.7
Protein Similarity:
100
90.9
N.A.
99
N.A.
96.5
95.5
N.A.
49.7
86.7
82
69.8
N.A.
49.3
54.9
N.A.
59.4
P-Site Identity:
100
0
N.A.
100
N.A.
86.6
6.6
N.A.
0
26.6
6.6
20
N.A.
6.6
13.3
N.A.
13.3
P-Site Similarity:
100
20
N.A.
100
N.A.
86.6
33.3
N.A.
0
40
13.3
33.3
N.A.
40
33.3
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
9
17
0
25
0
0
9
9
0
34
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
9
9
9
0
0
17
0
9
25
9
17
25
34
% D
% Glu:
9
25
17
50
17
34
25
0
42
17
9
17
0
25
17
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
9
0
0
0
9
9
25
9
9
9
9
0
17
9
0
% G
% His:
25
25
9
9
0
9
0
0
9
0
0
34
0
0
9
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
9
9
0
9
9
0
25
0
0
0
0
9
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% L
% Met:
0
0
0
0
9
9
0
9
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
9
0
0
0
9
0
0
0
9
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% P
% Gln:
0
0
0
0
0
9
9
0
9
9
9
9
0
9
0
% Q
% Arg:
17
0
9
0
0
9
0
0
0
9
0
17
9
9
0
% R
% Ser:
17
25
25
9
17
9
25
34
17
17
9
0
42
9
25
% S
% Thr:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _